MOTS-c 40mg – energy and mitochondrial support

What is MOTS-c?

This peptide helps cells use energy more economically and adapt better to fuel scarcity, which affects overall endurance and the metabolic balance of the organism.

As a mitochondrially-encoded peptide signal, MOTS-c activates AMP-activated protein kinase (AMPK) and energy-stress–related pathways, thereby redirecting cellular metabolism toward more efficient glucose utilization and control of lipid homeostasis (review and primary data: Wikipedia: MOTS-c; PubMed (search: MOTS-c AMPK)).

Mechanism of action 

MOTS-c is described as a peptide derived from the mitochondrial 12S rRNA region, with the potential to modulate an AMPK-dependent transcriptional program under metabolic stress and to influence insulin signaling in experimental models. In cell systems it is used to track effects on phosphorylation of AMPK/ACC, glucose uptake, mitochondrial function, and transcriptomic changes; it is often combined with Seahorse analysis, Western blot, and RT-qPCR panels for energy genes (context: PubMed).

Clinical/preclinical data 

Published materials on MOTS-c include preclinical and limited human observational/associative data, but available public sources do not provide sufficiently unified numerical parameters (n, doses, duration, and endpoints) for accurate B2B presentation in a standardized table without risk of speculation. Therefore, below is a table framework to be filled with data from specific articles that your team selects and verifies.

Context of use in laboratory and clinical settings

In the laboratory MOTS-c is applied as a tool for modeling energy stress and metabolic signaling, including experimental design with serum/glucose control, time-series (min–hours for signaling; days for adaptation) and comparison with AMPK modulators. In the clinical setting there is currently no regulatory-approved therapeutic use; for regulatory context see the public databases of the FDA and the EMA.

Pharmacokinetics (applicability for experimental design)

Publicly available PK parameters in humans are not standardized; in in vitro work it is recommended to plan concentration gradients and time points to distinguish rapid signaling effects from secondary transcriptional changes.

Purity and specification

MOTS-c from MyPeptid is suitable for analytical and functional tests, as it is provided with purity >99% (HPLC) and identity control (MS), which minimizes the risk of interferences in sensitive readouts.

Formula

Formula: C101H152N28O22

For educational and research purposes only (research-only); not intended for diagnostic or therapeutic use.