Immunomodulatory peptides

Immunomodulatory peptides are the subject of intensive basic and clinical research aimed at their impact on innate and adaptive immunity. Studies include in vitro and animal models, biomarker analyses and phases I–III clinical trials. The medical approach addresses dosing, delivery (local/systemic), safety profiles and combining with vaccines or anti-infective / oncological therapies to optimize response and minimize toxicity.

Most commonly observed positive effects in humans:

• Modulation of cytokine levels (decrease in pro-inflammatory, increase in regulatory cytokines)
• Improved resistance to infections and accelerated recovery
• Enhanced response to vaccines
• Promotion of wound healing and tissue regeneration
• Positive changes in the microenvironment in oncological therapies (increased immune infiltration)

These effects vary between individuals; medical evaluation and controlled clinical data are required for specific applications.