
Sermorelin е GHRH analogue, който стимулира natural release of growth hormone. It improves sleep quality, recovery, and muscle tone. It is used by athletes and people with an active lifestyle for rejuvenation and energy.
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With a brief signal to the body, this peptide can prompt the brain to amplify the natural impulses that govern the release of growth hormone, thereby altering the way growth, recovery, and metabolic processes are regulated.
What is Sermorelin?
Activation of the GHRH receptor (GPCR) in the anterior pituitary underlies the molecular class of sermorelin as a functional analogue of human growth hormone–releasing hormone (GHRH). It is a synthetic peptide corresponding to the N-terminal fragment (1–29) of endogenous GHRH, developed for research on the GHRH–GH–IGF-1 axis; descriptions and context are available on Wikipedia.
Mechanism of action
Binding to the GHRH receptor activates the Gs/adenylate cyclase system, increases cAMP, and stimulates PKA-dependent processes that augment the pulsatile release of GH from somatotrophs. For experimental design this means the effect is highly dependent on dosing timing and basal somatostatin tone; in in vitro models pituitary/somatotroph cell lines and cAMP/GH readouts are often used.
Data (limited and contextual)
| study name | population or experimental model | number of subjects or samples | duration | key observed outcomes |
|---|---|---|---|---|
| FDA labeling (historical): Geref diagnostic use | Pediatric assessment of GH secretion (diagnostic test) | not standardized in a single protocol | single administration/test | the public label lacks consistent numerical results for summarization; used to provoke a GH response |
Publicly available regulatory summaries for sermorelin as a diagnostic agent (Geref) and review sources describe the mechanistic framework, but do not provide a standardized set of comparable numerical efficacy results in a single population; see FDA and review articles on PubMed.
Context of scientific use and pharmacokinetic notes
In the laboratory setting, sermorelin is used to model receptor activation and GH release kinetics, as well as to calibrate bioanalytical methods (immunoassays for GH/IGF-1). Pharmacokinetically (as a peptide), rapid proteolysis and a short functional window after parenteral administration are expected, which is important when planning sampling time points and dynamic tests.
Purity and specification
Sermorelin from MyPeptid is intended for controlled research protocols, providing conditions for reproducible assays with declared purity above 99% (typically by HPLC) and batch traceability.
Formula: C149H246N44O42
For educational and research purposes only (B2B, research-only); not intended for clinical use or application in humans.